MULTIDISCIPLINARY JOURNAL OF INSTRUCTION (MDJI)
type: channel
publisher: Students Consultancy Home(R) (SCH)
language: en
publication name: MULTIDISCIPLINARY JOURNAL OF INSTRUCTION (MDJI)
issn: 2710-3161
items: Lobito Corridor's Impact on Angola-USA Trade Relations
items: Diaspora and Afro-Descendants in Angola–USA Business Relations
items: Establishing Level A IVIVC for Extended-Release Formulations: A Regulatory Perspective
items: Modeling First-Pass Metabolism: Advances in Predictive Algorithms for Hepatic Clearance
items: Bridging the Translational Gap: IVIVC in Personalized Medicine for Rare Diseases
items: Impact of Gut Microbiota on the Pharmacokinetics of Orally Administered Drugs
items: Comparative Pharmacokinetics of Biologics Versus Small Molecule Drugs in Disease States
items: Integration of Physiologically Based Pharmacokinetic (PBPK) Modeling with IVIVC for Precision Dosing
items: Machine Learning Models to Enhance Predictability of IVIVC in Early Drug Development
items: Role of Transporter Proteins in Tissue-Specific Drug Distribution and Elimination
items: IVIVC for Biopharmaceutical Classification System (BCS) Class II Drugs: Case Studies and Challenges
items: Federated Explainable AI for Privacy-Preserving Population Segmentation in Distributed Healthcare Systems
items: Adaptive Health Intervention for Older Adults Using Causal AI on Streaming Social and Behavioral Data
items: Decentralized Streaming-Based Monitoring of Post-Acute Care Outcomes via Blockchain-Integrated AI
items: Artificial Intelligence in Falls Management for Older Adult Care
items: Impact of Safety Culture on Incident Reporting in Developing Countries
items: Adaptive Multimodal AI for Early Detection of Cognitive Decline Using Real-Time Health Data and Wearables in Aged Care
items: Safety Culture and Incident Reporting in Developing Countries: An Empirical Analysis
items: Real-Time Analytics in Supply Chain Management: AI’s Role in Enhancing Visibility
items: Overcoming Human Bottlenecks in Finance Through BPA and AI Integration
items: Hyper-automation in Enterprises: Where AI Meets RPA for Maximum ROI
items: From Manual to Intelligent Workflows: Oracle Cloud’s Role in End-to-End Automation
items: Title: Automating Revenue Cycle Management in Healthcare with Oracle Cloud
items: AI AND RPA IN HEALTHCARE: REDUCING ADMINISTRATIVE LOAD AND ENHANCING PATIENT CARE
items: Explainable AI in Enterprise Decision Making: Bridging Transparency and Performance
items: AI in Finance: Real-Time Risk Detection and Fraud Prevention Mechanisms
items: The Role of Generative AI in Business Process Automation: From Chatbots to Intelligent Workflows
items: Migrating from Oracle EBS to Oracle Fusion Cloud: Best Practices and Pitfalls to Avoid
items: Oracle Fusion Cloud Financials: A Game-Changer for Agile Enterprises

Lobito Corridor's Impact on Angola-USA Trade Relations
type: item
description: As the Lobito Corridor infrastructure project, connecting Angola, Zambia, and the Democratic Republic of Congo to international markets through the Atlantic port of Lobito, nears completion, it is expected to bring about significant changes in the trade relationship between Angola and the United States. By providing a new transport link that enhances regional integration through rail, road, and associated infrastructure development, the corridor could reduce transportation costs, improve supply chain efficiency, and potentially expand Angola’s export capacity beyond oil. This paper will analyze the potential impacts of the Lobito Corridor on the volume and value of trade, export diversification, foreign direct investment, and overall economic growth between Angola and the United States. It will also consider the implications of the corridor for Angola’s efforts to transition to a more diversified and resilient economy, as well as the opportunities for American companies to invest in and benefit from the project. Additionally, the paper will explore the strategic importance of the corridor for the United States in terms of deepening infrastructure partnerships in Africa, diversifying global supply chains, and promoting ethical trade and good governance.
subject: Articles
  topic: section
subject: Lobito Corridor, Angola–United States Trade, Infrastructure Development, Export Diversification, Foreign Direct Investment (FDI)
  topic: keywords
creator: Fernando do Nascimento Casimiro M’Bachi,
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-07-10
publication date: 2025-07-10
starting page: 21
ending page: 25

Diaspora and Afro-Descendants in Angola–USA Business Relations
type: item
description: In this article, we discuss the increasing role of the Angolan diaspora and Afro-descendant communities in facilitating and expanding bilateral business and trade between Angola and the United States. We draw on the long historical ties between the two countries, dating back to the transatlantic slave trade, and the recent developments in diaspora engagement policies and initiatives. We analyze the contributions of people of Angolan descent or ancestry in the United States, as well as African Americans with roots in Angola, as a source of human and cultural capital for bilateral trade and investment. We provide examples of their involvement and impact in various sectors, such as oil and gas, agriculture, technology, and the creative economy. We also highlight the opportunities and challenges for increasing the participation and influence of the Angolan diaspora and Afro-descendants in the business and trade relations between Angola and the United States. We suggest some recommendations for both Angolan and U.S. stakeholders to enhance the potential of this growing and dynamic community for mutual benefit and cooperation.
subject: Articles
  topic: section
subject: Angolan Diaspora, Afro-Descendants, Bilateral Trade, Cultural and Economic Exchange, Diaspora Engagement
  topic: keywords
creator: Fernando do Nascimento Casimiro M’Bachi,
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-09-10
publication date: 2025-09-10
starting page: 1
ending page: 20

Establishing Level A IVIVC for Extended-Release Formulations: A Regulatory Perspective
type: item
description: Establishing a Level A In Vitro–In Vivo Correlation (IVIVC) is a critical step in the development and regulatory evaluation of extended-release (ER) drug formulations. Level A IVIVC provides a direct, point-to-point relationship between in vitro dissolution profiles and in vivo drug absorption, enabling reliable prediction of a drug’s pharmacokinetic behavior from laboratory tests. This correlation is particularly valuable for ER products, where controlled release mechanisms significantly influence therapeutic outcomes. From a regulatory perspective, Level A IVIVC supports streamlined product development, facilitates biowaivers for post-approval changes, and enhances risk management by reducing the need for extensive in vivo studies. This article explores the scientific principles, methodological approaches, and regulatory expectations underpinning the establishment of Level A IVIVC for ER formulations. Additionally, it highlights practical challenges, presents successful case studies, and discusses future trends shaping regulatory strategies and formulation innovation.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: Level A IVIVC, Extended-release formulations, In vitro–in vivo correlation, Regulatory guidance, Drug development, Biowaivers, Pharmacokinetics, Dissolution testing, Drug absorption, Formulation optimization
creator: Lawrence Paul
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-05-10
publication date: 2024-05-10
starting page: 452
ending page: 459

Modeling First-Pass Metabolism: Advances in Predictive Algorithms for Hepatic Clearance
type: item
description: First-pass metabolism, particularly hepatic clearance, plays a crucial role in determining the bioavailability and efficacy of orally administered drugs. Accurately predicting the extent of first-pass metabolism remains a critical challenge in pharmacokinetics and drug development. Traditional modeling approaches, such as compartmental and physiologically based pharmacokinetic (PBPK) models, offer valuable insights but often fall short in capturing the complexity and variability of hepatic drug metabolism. Recent advances in predictive algorithms, including machine learning and deep learning techniques, have opened new avenues for more accurate and individualized predictions of hepatic clearance. These data-driven models leverage large pharmacokinetic datasets, molecular descriptors, and omics data to improve prediction performance and generalizability. This article reviews current developments in algorithmic modeling of first-pass metabolism, discusses their integration with mechanistic approaches, and evaluates their potential applications and limitations in the drug development pipeline. The paper also highlights emerging trends such as hybrid modeling, the use of real-world data, and regulatory challenges that must be addressed for broader adoption.
subject: Articles
  topic: section
subject: First-pass metabolism, Hepatic clearance, Pharmacokinetics, Predictive algorithms, Machine learning, Deep learning, PBPK modeling, Drug metabolism, Bioavailability, Drug development
  topic: keywords
creator: James Oliver
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-04-10
publication date: 2024-04-10
starting page: 443
ending page: 451

Bridging the Translational Gap: IVIVC in Personalized Medicine for Rare Diseases
type: item
description: The development of effective therapies for rare diseases remains a significant challenge due to limited patient populations and complex disease mechanisms. Personalized medicine offers promising avenues to tailor treatments to individual patients, yet translating preclinical findings into clinical success often encounters a substantial translational gap. In vitro–in vivo correlation (IVIVC) serves as a critical tool in bridging this gap by enabling the prediction of clinical drug behavior from laboratory data. This article explores the pivotal role of IVIVC in advancing personalized medicine for rare diseases, highlighting its capacity to optimize dosing, enhance drug efficacy, and reduce adverse effects. By examining recent case studies and addressing current challenges, this review underscores the potential of IVIVC to transform therapeutic strategies, ultimately improving patient outcomes and accelerating drug development in the realm of rare diseases.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: In Vitro–In Vivo Correlation (IVIVC), Personalized Medicine, Rare Diseases, Translational Gap, Drug Development, Pharmacokinetics, Dose Optimization, Therapeutic Strategies, Clinical Translation, Biomarkers.
creator: Samuel Thomas
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-03-10
publication date: 2024-03-10
starting page: 437
ending page: 442

Impact of Gut Microbiota on the Pharmacokinetics of Orally Administered Drugs
type: item
description: The gut microbiota, a complex and dynamic ecosystem in the human gastrointestinal tract, plays a pivotal role in modulating the pharmacokinetics of orally administered drugs. These microorganisms can directly metabolize drugs, alter their chemical structure, and modulate host drug-metabolizing enzymes and transporters. Such interactions can significantly affect drug absorption, bioavailability, distribution, and elimination, leading to variability in therapeutic outcomes and adverse drug reactions. Recent advances in microbiome research have unveiled the profound influence of microbial composition and activity on drug efficacy and toxicity. This article reviews the mechanisms by which gut microbiota impact drug pharmacokinetics, discusses notable examples of microbiota–drug interactions, and explores these findings' clinical and therapeutic implications. Understanding these interactions is crucial for the development of personalized medicine strategies and the optimization of drug therapy in diverse patient populations.
subject: Articles
  topic: section
subject: Gut microbiota, Pharmacokinetics, Oral drug administration, Drug metabolism, Bioavailability, Microbiome–drug interactions, Personalized medicine, Microbial enzymes, Drug absorption, Gut-liver axis.
  topic: keywords
creator: Rahmon Leo
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-02-20
publication date: 2024-02-20
starting page: 429
ending page: 436

Comparative Pharmacokinetics of Biologics Versus Small Molecule Drugs in Disease States
type: item
description: Pharmacokinetics (PK) plays a critical role in optimizing drug therapy by elucidating how drugs are absorbed, distributed, metabolized, and eliminated in the body. Biologics and small-molecule drugs, two major classes of therapeutics, differ significantly in their molecular structure and pharmacokinetic behavior, particularly in pathological conditions. This article provides a comparative analysis of the pharmacokinetics of biologics versus small-molecule drugs in various disease states, highlighting how disease-associated physiological changes influence drug disposition. Key differences in absorption routes, metabolic pathways, distribution patterns, and clearance mechanisms are discussed, along with the impact of factors such as inflammation, organ dysfunction, and immunogenicity on drug kinetics. Understanding these distinctions is essential for tailoring dosing regimens, improving therapeutic efficacy, and minimizing toxicity. The review also addresses clinical implications and future directions in personalized medicine and pharmacokinetic modeling.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: Pharmacokinetics, Biologics, Small-molecule drugs, Disease states, Drug absorption, Drug metabolism, Drug distribution, Drug clearance, Immunogenicity, Therapeutic drug monitoring, Personalized medicine, Pharmacokinetic modeling
creator: Lawrence Paul
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-01-15
publication date: 2024-01-15
starting page: 421
ending page: 428

Integration of Physiologically Based Pharmacokinetic (PBPK) Modeling with IVIVC for Precision Dosing
type: item
description: Precision dosing aims to optimize therapeutic outcomes by tailoring drug administration to individual patient characteristics. Physiologically Based Pharmacokinetic (PBPK) modeling has emerged as a powerful tool for predicting drug absorption, distribution, metabolism, and excretion based on physiological and biochemical parameters. In parallel, In Vitro–In Vivo Correlation (IVIVC) facilitates the translation of in vitro drug dissolution data to in vivo performance, traditionally aiding in formulation development and regulatory decisions. Integrating PBPK modeling with IVIVC represents a promising strategy to enhance predictive accuracy in pharmacokinetics and support model-informed precision dosing. This article explores the scientific rationale, methodologies, and practical applications of this integrated approach. We discuss how the synergy between PBPK and IVIVC can improve drug development efficiency, reduce the need for extensive clinical trials, and enable personalized therapeutic regimens. Additionally, we highlight current challenges, such as data requirements and regulatory acceptance, and provide a forward-looking perspective on advancements in computational pharmacology that may further empower this integration.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: Physiologically Based Pharmacokinetic (PBPK) Modeling, In Vitro–In Vivo Correlation (IVIVC), Precision Dosing, Model-Informed Drug Development (MIDD), Pharmacokinetics, Drug Absorption, Personalized Medicine,Biopharmaceutics, Regulatory Science, Simulation and Modeling
creator: Harry John
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-01-20
publication date: 2024-01-20
starting page: 403
ending page: 411

Machine Learning Models to Enhance Predictability of IVIVC in Early Drug Development
type: item
description: In vitro–in vivo correlation (IVIVC) serves as a critical predictive tool in pharmaceutical research, linking in vitro drug release profiles to in vivo pharmacokinetic behavior. Despite its regulatory and developmental importance, traditional IVIVC models often struggle to capture the complex, nonlinear relationships inherent in drug absorption and metabolism, particularly for novel and extended-release formulations. Recent advances in machine learning (ML) offer promising solutions to enhance the predictability and robustness of IVIVC, leveraging large, multidimensional datasets and sophisticated pattern recognition capabilities. This article explores the integration of various ML models, including Random Forest, Support Vector Regression, Gradient Boosting, and Neural Networks, into IVIVC modeling frameworks during early drug development. We present a comparative analysis of model performances against conventional statistical methods, using real and simulated datasets, with a focus on predictive accuracy, model validation, and regulatory considerations. The findings demonstrate that ML-based approaches substantially improve IVIVC predictability, offering new avenues for optimizing formulation strategies and reducing the reliance on extensive in vivo testing. The study underscores the potential of artificial intelligence as a transformative tool in pharmaceutical sciences, advocating for its broader adoption in preclinical and early clinical research phases.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: Machine Learning, IVIVC, In Vitro–In Vivo Correlation, Drug Development, Pharmacokinetics, Predictive Modeling, Artificial Intelligence, Early-Phase Drug Research, Formulation Design, Regulatory Science
creator: Ajaxy Daniel
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-03-10
publication date: 2024-03-10
starting page: 395
ending page: 402

Role of Transporter Proteins in Tissue-Specific Drug Distribution and Elimination
type: item
description: Transporter proteins play a critical role in determining the tissue-specific distribution and elimination of drugs, significantly influencing their pharmacokinetic profiles and therapeutic efficacy. These membrane-bound proteins, including influx and efflux transporters from major families such as ATP-binding cassette (ABC) and solute carrier (SLC) transporters, regulate the uptake and efflux of drugs across cellular barriers in various tissues. The differential expression of transporter proteins in organs like the liver, kidney, brain, and intestine contributes to distinct drug distribution patterns and elimination pathways, affecting drug bioavailability, clearance, and toxicity. Understanding the mechanisms by which transporter proteins mediate drug movement is essential for predicting drug interactions, variability in patient response, and optimizing drug design. This article reviews the current knowledge on the role of transporter proteins in tissue-specific drug distribution and elimination, highlighting their clinical significance and potential as therapeutic targets.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: Transporter Proteins,mTissue-Specific Drug Distribution, Drug Elimination, Pharmacokinetics, ABC Transporters, SLC Transporters, Drug Clearance, Drug-Drug Interactions, Membrane Transport, Personalized Medicine
creator: Johnson Laurel
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-02-10
publication date: 2024-02-10
starting page: 388
ending page: 394

IVIVC for Biopharmaceutical Classification System (BCS) Class II Drugs: Case Studies and Challenges
type: item
description: In vitro–in vivo correlation (IVIVC) serves as a pivotal tool in drug development, enabling the prediction of in vivo drug performance based on in vitro dissolution data. This approach is particularly valuable for Biopharmaceutical Classification System (BCS) Class II drugs, which are characterized by low solubility and high permeability, making dissolution the rate-limiting step in absorption. Despite the theoretical suitability of IVIVC for this class, the practical application often presents significant challenges due to complex gastrointestinal dynamics and formulation-dependent variability. This article provides an in-depth review of IVIVC in the context of BCS Class II drugs, highlighting regulatory perspectives, technical hurdles, and formulation strategies. Through detailed case studies, ranging from successful correlations to partial or failed attempts, we explore the critical factors influencing the establishment of robust IVIVCs. Emerging approaches such as the use of biorelevant media, physiologically based pharmacokinetic (PBPK) modeling, and advanced in vitro systems are also discussed as potential solutions to current limitations. The insights presented aim to guide formulation scientists and regulatory professionals in navigating the complexities of IVIVC for BCS Class II compounds.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: IVIVC, BCS Class II, Biopharmaceutical Classification System, In vitro–in vivo correlation, Drug dissolution, Oral drug delivery, Low solubility drugs, PBPK modeling, Biorelevant media, Regulatory guidance
creator: Harry John
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-01-10
publication date: 2024-01-10
starting page: 380
ending page: 387

Federated Explainable AI for Privacy-Preserving Population Segmentation in Distributed Healthcare Systems
type: item
description: Abstract: Healthcare data complexity and sensitivity create major obstacles for traditional data analysis methods due to the presence of strict privacy regulations. Federated Learning (FL) working together with Explainable Artificial Intelligence (XAI) presents an innovative approach to enable privacy-protected population segmentation throughout dispersed healthcare networks. Through investigating FL and XAI integration this paper demonstrates how electronic health record (EHR) usage can be both collaborative and transparent while maintaining ethical standards without violating data ownership rights or patient confidentiality. The research evaluates existing federated models while recognizing issues like data diversity and network delays and underscores XAI's contribution to model interpretation. The paper stresses the critical need for collaborative efforts between institutions while highlighting the requirement for robust infrastructure protection against malicious threats and the opportunities provided by cutting-edge methods including homomorphic encryption and blockchain. The results demonstrate that FL-XAI frameworks can greatly improve public health insights derived from data while allowing medical interventions to become more fair, accurate, and transparent. Clinical environments require standardized data harmonization protocols alongside scalable federated architectures investments to achieve broader real-world application.
subject: Articles
  topic: section
subject: Federated Learning, Explainable AI, Privacy-Preserving Machine Learning, Population Health Segmentation, Electronic Health Records, Healthcare Data Security
  topic: keywords
creator: Micheal Ressler Thomas
creator: Ken Ferison Smith
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-07-10
publication date: 2024-07-10
starting page: 371
ending page: 379

Adaptive Health Intervention for Older Adults Using Causal AI on Streaming Social and Behavioral Data
type: item
description: Healthcare infrastructures worldwide face growing pressure to provide individualized and forward-thinking care for aging populations. Traditional healthcare models frequently fail to meet the needs of people dealing with long-term illnesses or physical movement limitations. This research examines how real-time social and behavioral data streams, enhanced by causal AI, can revolutionize adaptive health interventions. Causal AI utilizes wearable sensors, environmental monitors, and social media activity to identify the root causes of health changes, leading to early and tailored interventions. Personalized support systems powered by AI dynamically respond to changing health conditions and contextual factors, delivering medication reminders as well as assistance with mental health engagement and social connectivity. The study demonstrates that a comprehensive, data-driven approach facilitates the implementation of a 4P medicine framework, which improves the early detection of diseases while supporting personalized treatment planning and enhancing quality of life through predictive and participatory medical practices.
subject: Articles
  topic: section
subject: Adaptive Health intervention, older adults using casual AI, Behavioral Data, Streaming Social
  topic: keywords
creator: Sunil Pulikkal,
creator: Renjith O. Mahara
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-07-10
publication date: 2024-07-10
starting page: 357
ending page: 370

Decentralized Streaming-Based Monitoring of Post-Acute Care Outcomes via Blockchain-Integrated AI
type: item
description: As HealthcareHealthcare undergoes swift digital transformation, it creates new possibilities for enhancing post-acute care through advanced technological solutions. This study introduces a decentralized monitoring system that utilizes blockchain technology and artificial intelligence (AI) to track post-acute care outcomes in real time. Post-acute care services, including rehabilitation and skilled nursing, need real-time secure data monitoring that focuses on patients to help improve recovery and minimize hospital readmissions. The system design incorporates Internet of Things (IoT) devices, along with wearable sensors, to gather ongoing physiological and behavioral information from patients. Edge computing processes this data to maintain efficiency before it gets securely transmitted to a decentralized network where smart contracts and blockchain technology together ensure data immutability and provenance. Embedded AI algorithms within the system conduct real-time analytics to identify patterns and risks, enabling prompt clinical interventions.
subject: Articles
  topic: section
subject: Blockchain in Healthcare, AI-Driven Post-Acute Care, Decentralized Health Monitoring, Real-Time Patient Analytics, IoT and Edge Computing in Medicine
  topic: keywords
creator: Adeferasin Esther Oluyole
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-07-10
publication date: 2024-07-10
starting page: 338
ending page: 356

Artificial Intelligence in Falls Management for Older Adult Care
type: item
description: Older adults face significant public health difficulties from falls that lead to serious injuries alongside loss of independence and greater healthcare spending. The study examines how Artificial Intelligence (AI) can revolutionize fall risk management in geriatric care settings. The combination of machine learning algorithms with data from wearable sensors, along with electronic health records and environmental monitoring systems, enables AI to deliver proactive and personalized risk assessments as well as early fall detection with real-time intervention strategies. Caregivers gain continuous, personalized care capabilities through the integration of AI technology, which includes ambient intelligence and remote patient monitoring systems that help reduce the impact of falls. The study examines existing AI technologies used for fall prevention, evaluating their medical implications and suggesting future advancements to enhance the safety and well-being of the elderly.
subject: Articles
  topic: section
subject: Fall management, adult care, fall prevention, Safety and Wellbeing
  topic: keywords
creator: Rhoda Christiana Loveth,
creator: Elizabeth Clark
creator: Prius Ayim Nora
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-07-10
publication date: 2024-07-10
starting page: 315
ending page: 337

Impact of Safety Culture on Incident Reporting in Developing Countries
type: item
description: This research examines how safety culture affects incident reporting practices within developing nations, focusing on the healthcare and construction industries, which carry high risks. The research demonstrates that open communication, psychological safety, and nonpunitive error responses form the basis of a strong safety culture that promotes transparent incident reporting. The study employs mixed-methods research to combine quantitative surveys with qualitative interviews, assessing the effects of organizational attitudes, leadership commitment, and communication structures on employees' readiness to report safety events. Research findings indicate that organizational environments characterized by blame-based cultures and hierarchical systems, combined with inadequate feedback mechanisms, negatively impact reporting practices. When organizations foster trust among employees, alongside team collaboration and leadership advocacy, they experience an increase in safety reports and improved outcomes.
subject: Articles
  topic: section
subject: Safety Culture, Incident Reporting, Developing Countries, Healthcare Safety, Nonpunitive Environment
  topic: keywords
creator: Olakunle Lawal
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-07-10
publication date: 2024-07-10
starting page: 295
ending page: 314

Adaptive Multimodal AI for Early Detection of Cognitive Decline Using Real-Time Health Data and Wearables in Aged Care
type: item
description: The increasing number of elderly individuals worldwide makes early cognitive decline detection vital for handling conditions such as Alzheimer's disease. Traditional diagnostic approaches, which rely on neuropsychological testing in clinical settings, often lack scalability and accessibility and are unsuitable for continuous monitoring. The research examines how adaptive multimodal Artificial Intelligence (AI) systems, combined with wearable health technologies, can facilitate the immediate detection of cognitive impairment in aged care environments. Wearable devices, such as accelerometers and heart rate monitors, produce detailed physiological and behavioral data streams that combine with electronic health records and self-reports to generate comprehensive multimodal datasets. Machine learning algorithms, combined with deep learning frameworks such as recurrent and convolutional neural networks, analyze these datasets to identify patterns that indicate mild cognitive impairment. The predictive systems identify early gait irregularities and changes in heart rate variability and sleep patterns, enabling proactive management of dementia.
subject: Articles
  topic: section
subject: Multimodal Artificial Intelligence (AI), Cognitive Decline Detection, Wearable Health Technology, Aged Care Monitoring, Explainable AI in Healthcare
  topic: keywords
creator: Augustin Brian Roy1, Parian S. Joecel2, Collins Naing Foster3, Adam Marwan4
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-07-10
publication date: 2024-07-10
starting page: 276
ending page: 294

Safety Culture and Incident Reporting in Developing Countries: An Empirical Analysis
type: item
description: This study examines the interaction between safety culture and incident reporting practices in developing countries, highlighting the significant influence of cultural, socio-economic, and systemic factors on reporting behaviors. This research employs both quantitative surveys and qualitative interviews to investigate how dimensions of organizational safety culture, including management commitment and communication, impact incident reporting statistics. Organizations that maintain a strong safety culture achieve significantly higher reporting rates, underscoring the crucial role of leadership engagement, open communication, and ongoing learning in safety practices. The research identified fear of reprisal, insufficient resources, and hierarchical workplace structures as principal obstacles. The research reveals that interventions must be customized to develop safety cultures that enable transparent reporting and better safety results. Leadership-driven initiatives combined with enhanced training programs and robust reporting systems provide an effective strategy for building a culture of safety in developing contexts.
subject: Articles
  topic: section
subject: Safety Culture, Incident reporting, Management commitment,
  topic: keywords
creator: Mamukuyomi Samuel Segun
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-07-10
publication date: 2024-07-10
starting page: 266
ending page: 275

Real-Time Analytics in Supply Chain Management: AI’s Role in Enhancing Visibility
type: item
description: In the dynamic landscape of global commerce, supply chain visibility has emerged as a critical determinant of operational efficiency and resilience. This paper explores the transformative role of Artificial Intelligence (AI) in enabling real-time analytics within supply chain management (SCM), with a particular emphasis on enhancing end-to-end visibility. Traditional supply chains often suffer from fragmented data, delayed insights, and reactive decision-making. However, the integration of AI technologies such as machine learning, computer vision, natural language processing, and IoT devices has empowered organizations to process large volumes of data in real-time, detect anomalies, forecast disruptions, and optimize logistics workflows proactively.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: Real-Time Analytics, Supply Chain Management, Artificial Intelligence, Supply Chain Visibility, Machine Learning, IoT, Predictive Analytics, Logistics Optimization, Data-Driven Decision Making, Digital Supply Chain
creator: Olivia Carter,
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-01-10
publication date: 2024-01-10
starting page: 226
ending page: 237

Overcoming Human Bottlenecks in Finance Through BPA and AI Integration
type: item
description: In today’s rapidly evolving financial landscape, organizations face increasing pressure to optimize operations, improve accuracy, and accelerate decision-making. One of the most significant challenges is the human bottlenecks that arise from manual processes in tasks such as data entry, reconciliation, reporting, and compliance management. These bottlenecks hinder overall efficiency, increase the risk of errors, and slow down response times, ultimately impacting the bottom line. Business Process Automation (BPA), coupled with Artificial Intelligence (AI), presents a solution to eliminate these inefficiencies by automating routine tasks, optimizing workflows, and supporting intelligent decision-making. This paper explores the integration of BPA and AI in finance, highlighting how these technologies can streamline operations, reduce operational costs, and improve both speed and accuracy. The study provides an overview of the benefits of automating key financial processes, from invoice processing and expense management to fraud detection and financial forecasting. Case studies from leading financial institutions illustrate the tangible outcomes achieved through automation, including reduced processing times, improved compliance, and increased profitability. By integrating AI-driven analytics with BPA tools, organizations can enhance their financial agility and scalability while reducing the reliance on manual intervention, ultimately overcoming traditional human bottlenecks. The paper concludes with recommendations for effectively implementing BPA and AI in financial operations and strategies for overcoming the barriers to successful adoption.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: Business Process Automation (BPA), Artificial Intelligence (AI), Financial Bottlenecks, Finance Automation, Financial Processes, Process Optimization, Fraud Detection, Invoice Processing, Financial Reporting, AI in Finance, Expense Management, Financial Forecasting, Compliance Automation, Operational Efficiency, Financial Technology (FinTech), Robotic Process Automation (RPA), Intelligent Automation, AI Integration, Data Entry Automation, Financial Agility, Digital Transformation, AI-Driven Analytics, Financial Decision Making, Business Process Optimization, Automation Adoption in Finance, Financial Institutions, Operational Cost Reduction, Intelligent Workflow Automation.
creator: Mia Lewis,
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-01-10
publication date: 2024-01-10
starting page: 247
ending page: 265

Hyper-automation in Enterprises: Where AI Meets RPA for Maximum ROI
type: item
description: Hyper-automation is reshaping enterprise operations by integrating Artificial Intelligence (AI) with Robotic Process Automation (RPA) to optimize efficiency, reduce operational costs, and enhance return on investment (ROI). This paper explores the convergence of these technologies and their role in driving digital transformation. Through a literature review, methodology analysis, and result-based discussion, we examine how enterprises leverage hyper-automation to maintain competitiveness and foster innovation. The study reveals key insights into implementation strategies, challenges, and best practices.
subject: Articles
  topic: section
subject: Hyper-automation, Artificial Intelligence, Robotic Process Automation, ROI, Digital Transformation, Enterprise Automation, Intelligent Automation
  topic: keywords
creator: Charlotte Hall,
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-01-10
publication date: 2024-01-10
starting page: 230
ending page: 246

From Manual to Intelligent Workflows: Oracle Cloud’s Role in End-to-End Automation
type: item
description: The rapid evolution of enterprise technology has driven a major shift from manual, fragmented processes to intelligent, automated workflows. At the heart of this transformation lies cloud computing—particularly platforms like Oracle Cloud Infrastructure (OCI)—which enables seamless integration of data, applications, and advanced automation tools. This paper explores Oracle Cloud’s role in facilitating end-to-end workflow automation, focusing on how its ecosystem leverages AI, machine learning, process orchestration, and data analytics to streamline operations and enhance decision-making. Through a combination of literature analysis, case studies, and enterprise use cases, the research highlights Oracle’s impact in key industries including finance, supply chain, human capital management, and customer experience. The study outlines how Oracle's suite of services—from Oracle Integration Cloud and Autonomous Database to AI Services and Digital Assistant—creates a robust foundation for intelligent process automation, enabling organizations to reduce operational costs, eliminate silos, and boost agility. The findings suggest that enterprises adopting Oracle Cloud for automation see measurable improvements in process speed, data accuracy, and resource optimization, while also enabling a more scalable and resilient digital infrastructure. However, the paper also acknowledges challenges such as migration complexity and skill gaps. The conclusion offers strategic insights for organizations seeking to move from traditional manual operations to intelligent, cloud-enabled workflows using Oracle's automation capabilities.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: Oracle Cloud, Workflow Automation, Intelligent Workflows, Cloud Infrastructure, End-to-End Automation, Process Orchestration, Machine Learning, AI in Automation, Oracle Integration Cloud, Autonomous Database, Digital Transformation, Business Process Automation, Data Analytics, Cloud Strategy, ERP Automation, Intelligent Applications, OCI, Cloud-native Automation, Enterprise Integration, Robotic Process Automation (RPA).
creator: Lucas Walker,
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-01-10
publication date: 2024-01-10
starting page: 213
ending page: 229

Title: Automating Revenue Cycle Management in Healthcare with Oracle Cloud
type: item
description: Revenue Cycle Management (RCM) is the cornerstone of financial sustainability in healthcare organizations, encompassing the entire financial process from patient registration to final payment collection. Traditional RCM systems are often hampered by inefficiencies such as manual data entry, fragmented information systems, billing errors, and regulatory non-compliance, which collectively result in delayed reimbursements and increased operational costs. With the growing demand for streamlined healthcare operations and value-based care, automation has emerged as a pivotal solution to modernize and optimize RCM processes. This paper explores the transformative role of Oracle Cloud in automating RCM within the healthcare sector. Leveraging a comprehensive suite of cloud-based solutions—including Artificial Intelligence (AI), Machine Learning (ML), Robotic Process Automation (RPA), and real-time analytics—Oracle Cloud empowers healthcare organizations to enhance operational efficiency, improve claim accuracy, accelerate reimbursements, and ensure regulatory compliance. By integrating seamlessly with Electronic Health Records (EHRs), Customer Relationship Management (CRM) systems, and Enterprise Resource Planning (ERP) platforms, Oracle Cloud creates a unified data environment that reduces administrative burden and supports informed decision-making. The study further examines real-world implementations by leading healthcare institutions, highlighting measurable outcomes such as reduced billing cycle times, increased claim acceptance rates, and improved patient satisfaction. While the adoption of Oracle Cloud presents certain challenges—including implementation complexity, data privacy concerns, and cost considerations—these can be mitigated through strategic planning and collaboration with technology partners. Ultimately, automating RCM using Oracle Cloud not only addresses the financial pain points of healthcare providers but also aligns with the broader objectives of hea…
subject: Articles
  topic: section
creator: Patric David
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-01-10
publication date: 2024-01-10
starting page: 202
ending page: 212

Title: Automating Revenue Cycle Management in Healthcare with Oracle Cloud
type: item
description: Revenue Cycle Management (RCM) is the cornerstone of financial sustainability in healthcare organizations, encompassing the entire financial process from patient registration to final payment collection. Traditional RCM systems are often hampered by inefficiencies such as manual data entry, fragmented information systems, billing errors, and regulatory non-compliance, which collectively result in delayed reimbursements and increased operational costs. With the growing demand for streamlined healthcare operations and value-based care, automation has emerged as a pivotal solution to modernize and optimize RCM processes. This paper explores the transformative role of Oracle Cloud in automating RCM within the healthcare sector. Leveraging a comprehensive suite of cloud-based solutions—including Artificial Intelligence (AI), Machine Learning (ML), Robotic Process Automation (RPA), and real-time analytics—Oracle Cloud empowers healthcare organizations to enhance operational efficiency, improve claim accuracy, accelerate reimbursements, and ensure regulatory compliance. By integrating seamlessly with Electronic Health Records (EHRs), Customer Relationship Management (CRM) systems, and Enterprise Resource Planning (ERP) platforms, Oracle Cloud creates a unified data environment that reduces administrative burden and supports informed decision-making. The study further examines real-world implementations by leading healthcare institutions, highlighting measurable outcomes such as reduced billing cycle times, increased claim acceptance rates, and improved patient satisfaction. While the adoption of Oracle Cloud presents certain challenges—including implementation complexity, data privacy concerns, and cost considerations—these can be mitigated through strategic planning and collaboration with technology partners. Ultimately, automating RCM using Oracle Cloud not only addresses the financial pain points of healthcare providers but also aligns with the broader objectives of hea…
subject: Articles
  topic: section
creator: Ethan Mitchell,
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-01-10
publication date: 2024-01-10
starting page: 191
ending page: 201

AI AND RPA IN HEALTHCARE: REDUCING ADMINISTRATIVE LOAD AND ENHANCING PATIENT CARE
type: item
description: The healthcare industry is undergoing a paradigm shift driven by rapid technological advancements and an increasing need for efficiency, cost reduction, and improved patient outcomes. Two of the most transformative technologies at the heart of this evolution are Artificial Intelligence (AI) and Robotic Process Automation (RPA). This article provides a comprehensive analysis of how these technologies are reshaping the healthcare landscape by alleviating administrative burdens and enhancing the quality of patient care. Administrative inefficiencies—such as medical billing, claims processing, appointment scheduling, and record management—consume significant time and resources, contributing to provider burnout, increased operational costs, and reduced focus on patient interaction. AI technologies, including machine learning and natural language processing, are now being used to analyze large datasets, make predictive decisions, and automate complex processes such as diagnosis assistance, treatment planning, and clinical documentation. RPA complements this by automating repetitive, rule-based tasks with precision and speed, enabling seamless data handling, real-time insurance verification, and automated communication systems. Together, AI and RPA form a powerful synergy, often referred to as Intelligent Automation, that not only improves operational efficiency but also supports clinicians in delivering more personalized and timely care. The article delves into real-world applications, from hospitals using AI for predictive analytics in patient deterioration, to health insurers deploying RPA bots to manage claims processing at scale. It also discusses the challenges of implementation, including data privacy, system interoperability, workforce adaptation, and ethical concerns related to AI decision-making. By examining these technologies through a multi-dimensional lens—technical, operational, ethical, and strategic—this article offers deep insights into how AI and RPA are…
subject: Articles
  topic: section
creator: Martin cowell,
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-01-10
publication date: 2024-01-10
starting page: 182
ending page: 190

Explainable AI in Enterprise Decision Making: Bridging Transparency and Performance
type: item
description: Abstract As artificial intelligence (AI) systems increasingly inform enterprise decision-making, the need for transparency and accountability grows. While AI models offer remarkable performance, their black-box nature poses significant challenges for trust and interpretability. This paper explores the intersection of explainable AI (XAI) and enterprise decision-making, focusing on how organizations can balance the trade-off between model transparency and performance. Through an extensive literature review and in-depth case study analysis, we propose a conceptual framework to bridge the gap, offering practical insights into adopting XAI without compromising efficiency. The study contributes to both academic discourse and industry practice by guiding enterprises toward responsible, high-performing AI integration.
subject: Articles
  topic: section
subject: Explainable AI, Enterprise Decision Making, Transparency, AI Performance, Trust in AI, Responsible AI, AI Governance, XAI Frameworks
  topic: keywords
creator: a
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-01-10
publication date: 2024-01-10
starting page: 173
ending page: 181

AI in Finance: Real-Time Risk Detection and Fraud Prevention Mechanisms
type: item
description: The financial industry has been increasingly leveraging Artificial Intelligence (AI) technologies to improve operational efficiency, enhance customer experience, and strengthen security frameworks. One of the most crucial areas where AI is making significant strides is in the detection of real-time risks and fraud prevention mechanisms. Traditional methods of managing risk and fraud have proven to be reactive and often fail to identify threats in time, leading to substantial financial losses. In contrast, AI-based systems offer proactive and dynamic solutions that can detect anomalies and predict risks before they escalate into major issues. This paper explores the application of AI in real-time risk detection and fraud prevention within financial institutions. By utilizing machine learning, deep learning, and anomaly detection algorithms, AI systems are able to analyze vast amounts of transaction data, detect irregular patterns, and generate instant alerts, thereby preventing potential financial crimes. The research highlights key AI techniques, evaluates case studies, and examines challenges faced by institutions adopting AI technologies. It also explores the ethical, regulatory, and operational concerns surrounding the deployment of AI in the financial sector. The paper concludes by offering recommendations for future AI-driven innovations in risk and fraud management and the steps needed to enhance their effectiveness.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: AI in Finance, Real-Time Risk Detection, Fraud Prevention, Machine Learning, Deep Learning, Anomaly Detection, Predictive Analytics, Financial Institutions, Behavioral Analysis, Natural Language Processing, Risk Management, Fraud Prevention Systems.
creator: Ava Robinson,
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-01-10
publication date: 2024-01-10
starting page: 159
ending page: 172

The Role of Generative AI in Business Process Automation: From Chatbots to Intelligent Workflows
type: item
description: Generative Artificial Intelligence (AI) is revolutionizing Business Process Automation (BPA), enabling organizations to move beyond rule-based systems to intelligent, adaptive workflows. From conversational chatbots to AI-driven content generation and decision-making, generative models like GPT and Claude are being integrated into various business functions, enhancing efficiency, personalization, and innovation. This paper explores the transformative role of generative AI in automating and optimizing business processes. Through a comprehensive review of existing technologies, use cases, benefits, and challenges, the study provides insights into the evolving landscape of intelligent automation and the strategic implications for future-ready enterprises.
subject: Articles
  topic: section
subject: Generative AI, Business Process Automation, Intelligent Workflows, Chatbots, Digital Transformation, Automation, AI in Business, GPT, AI Agents, Workflow Optimization
  topic: keywords
creator: Sophia Martin,
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-01-10
publication date: 2024-01-10
starting page: 151
ending page: 158

Migrating from Oracle EBS to Oracle Fusion Cloud: Best Practices and Pitfalls to Avoid
type: item
description: The transition from Oracle E-Business Suite (EBS) to Oracle Fusion Cloud Applications represents a significant shift in enterprise resource planning (ERP) systems, offering organizations enhanced agility, scalability, and innovation. However, such a migration is complex and requires strategic planning and execution to avoid common pitfalls. This research article explores the motivations behind the shift to Oracle Fusion Cloud, outlines best practices for a successful migration, and highlights the challenges organizations often encounter. By combining insights from case studies, industry reports, and expert recommendations, the article provides a comprehensive roadmap to ensure a smooth and value-driven migration journey.
subject: Articles
  topic: section
subject: Oracle EBS, Oracle Fusion Cloud, ERP migration, cloud transformation, best practices, data migration, customization challenges, change management, and digital strategy are central to the study’s focus
  topic: keywords
creator: Mason Clark, `
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-01-10
publication date: 2024-01-10
starting page: 139
ending page: 150

Oracle Fusion Cloud Financials: A Game-Changer for Agile Enterprises
type: item
description: In an era where business agility is crucial for sustained growth and competitiveness, cloud-based solutions are becoming essential for modern enterprises. Oracle Fusion Cloud Financials stands out as a transformative tool that enables businesses to streamline financial operations, enhance decision-making, and drive strategic growth. This research examines the impact of Oracle Fusion Cloud Financials on enterprises, particularly focusing on how it supports financial agility and enhances overall operational efficiency. The article explores the core features and capabilities of Oracle Fusion Cloud Financials, its role in automating financial processes, improving real-time decision-making, and fostering greater financial transparency. Through case studies, the paper demonstrates how various enterprises have leveraged the platform to achieve a competitive edge. A comparative analysis of Oracle Fusion Cloud Financials and other financial management systems highlights its unique advantages and challenges. Ultimately, this study underscores the significance of adopting cloud-based financial solutions like Oracle Fusion Cloud Financials as a game-changer for agile enterprises in the digital age.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: Oracle Fusion Cloud Financials, Agile Enterprises, Financial Management, Cloud Computing, Financial Automation, Real-Time Decision-Making, Business Agility, Enterprise Financial Systems, Cloud-based Solutions, Financial Transformation
creator: Isabella Moore,
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-01-10
publication date: 2024-01-10
starting page: 126
ending page: 138